Noun
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the feeling that everything is wrong and nothing will turn out well
"they moaned in despair and dismay"
"one harsh word would send her into the depths of despair"
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a state in which all hope is lost or absent
"in the depths of despair"
"they were rescued from despair at the last minute"
"courage born of desperation"
Verb
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abandon hope
give up hope
lose heart
"Don't despair--help is on the way!"