"those children are a damn plague"
any large scale calamity (especially when thought to be sent by God)
a swarm of insects that attack plants
"a plague of grasshoppers"
any epidemic disease with a high death rate
a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal
annoy continually or chronically
"He is known to harry his staff when he is overworked"
"This man harasses his female co-workers"
cause to suffer a blight
"Too much rain may blight the garden with mold"